Gemcitabine (elaidate) ( CP-4126; CO-101; Gemcitabine 5'-elaidate )

产品货号. M23957 CAS No. 210829-30-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Gemcitabine (elaidate)
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Gemcitabine elaidate, is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity.?
产品描述

Gemcitabine elaidate, is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity.?Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase.?dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis;?dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.
同义词

CP-4126; CO-101; Gemcitabine 5'-elaidate
通路

Autophagy
靶点

Autophagy
受体

Autophagy;Apoptosis
研究领域

——
适应症

——

CAS Number

210829-30-4
分子量

527.6
分子式

C27H43F2N3O5
纯度

>98% (HPLC)
溶解度

DMSO:26 mg/mL (49.28 mM);H2O:< 0.1 mg/mL (insoluble)
SMILES

CCCCCCCC/C=C/CCCCCCCC(OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)C(F)(F)[C@@H]1O)=O
化学全称

——

计算器

产品手册

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